Trichotillomania at times resembles Obsessive-Compulsive Disorder (OCD) in the feelings of compulsion and repetitive behavior, but the two disorders have different symptoms and require different treatments. Trichotillomania may also resemble a tic disorder, as the action of pulling feels automatic and is preceded by an uncomfortable sensation that must be relieved.

Similarities between obsessive-compulsive disorder (OCD) and trichotillomania (TTM) have been widely recognized. Nevertheless, there is evidence of important differences between these two disorders. Many people with trichotillomania try to stop the behavior but feel unable to do so. At times, these behaviors are consciously and intentionally performed as a means of coping with powerful or painful emotions. However, unlike OCD compulsions, people with hair-pulling disorder report a pleasurable gratification from hair pulling.

Naturopathy or naturopathic medicine is a form of alternative medicine employing a wide array of pseudoscientific practices branded as "natural" and as promoting "self-healing," including homeopathy, herbalism, and acupuncture, as well as diet and lifestyle counseling. Natural treatments for trichotillomania can be a health care practice that does not follow generally accepted medical methods and may not have a scientific explanation for its effectiveness. Examples of alternative medicines are homeopathy and herbal medicine and may involve biofeedback or acupuncture.